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THE EFFECT OF CHORIONIC GONADOTROPHIN AND CHORIONIC SOMATOMAMMOTROPHIN ON STEROIDOGENESIS IN THE CORPUS LUTEUM
Author(s) -
Stock R. J.,
Josimovich J. B.,
Kosor B.,
Klopper A.,
Wilson G. R.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00314.x
Subject(s) - pregnanediol , luteal phase , corpus luteum , excretion , endocrinology , medicine , menstruation , hormone , menstrual cycle
Summary Human chorionic gonadotrophin was given every other day to 8 women during 11 luteal phases and their excretion of oestrone and pregnanediol compared with the excretion of these steroids during an untreated luteal phase. Some of these subjects were also given chorionic somatomammotrophin while being treated with chorionic gonadotrophin. It was found that treatment with chorionic gonadotrophin resulted in an increase of ovarian hormone excretion and that the steroid levels remained elevated while the onset of menstruation was postponed. A decline in steroid excretion and menstruation eventually occurred in spite of continued treatment with chorionic gonadotrophin. There was no evidence that the administration of chorionic somatomammotrophin had any effect on ovarian steroidogenesis.