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SPECTROFLUORIMETRIC ASSAY OF SERUM CYSTINE AMINOPEPTIDASE IN NORMAL AND DIABETIC PREGNANCY COMPARED WITH TOTAL OESTROGEN EXCRETION
Author(s) -
Chapman L.,
Silk E.,
Skupny A.,
Tooth E. A.,
Barnes A.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00298.x
Subject(s) - aminopeptidase , cystine , endocrinology , excretion , chemistry , urinary system , medicine , pregnancy , urine , diabetes mellitus , enzyme , leucine , biochemistry , biology , amino acid , cysteine , genetics
Summary A spectrofluorimetric method for the assay of serum cystine aminopeptidase, an enzyme normally produced in increasing amounts during pregnancy, has been evaluated. The clinical application of this method in normal and diabetic pregnancies has been compared with that of measuring urinary total oestrogens. There is a statistically significant difference in cystine aminopeptidase values in diabetic patients whereas no such difference could be demonstrated when using total oestrogen assay.