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THE EFFECT OF DEXAMETHASONE ON THE URINARY EXCRETION OF STEROIDS DURING PREGNANCY
Author(s) -
Charles David,
Pinkus Jack L.,
Fanous Raouf,
Chattoraj Sati C.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00262.x
Subject(s) - pregnanediol , pregnenolone , endocrinology , dexamethasone , excretion , medicine , urinary system , estriol , chemistry , placenta , fetus , pregnancy , estrone , estrogen , steroid , biology , hormone , genetics
Summary The urinary excretion of oestriol, total 17‐oxosteroids, pregnanediol and Pettenkofer chromogens were studied in eight pregnancies before, during and after the administration of dexamethasone. Both the oestriol and 17‐oxosteroid levels declined during the period of drug administration. The change in Pettenkofer chromogens was less consistent but generally paralleled the 17‐oxosteroid values. Pregnanediol excretion greatly increased in three subjects, decreased in one and was relatively unchanged in the other patients. The present studies support the concept that placental pregnenolone is utilized by the fetal tissues for the biosynthesis of oestrogen precursors and by the placenta for progesterone synthesis.