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GONADAL MALIGNANCY IN XY FEMALES
Author(s) -
Dewhurst C. J.,
Ferreira H. P.,
Gillett P. G.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00228.x
Subject(s) - malignancy , androgen insensitivity syndrome , androgen , chromosome , y chromosome , medicine , biology , gynecology , endocrinology , androgen receptor , cancer , genetics , hormone , prostate cancer , gene
Summary This paper considers malignant testicular tumour formation in 76 phenotypic female patients possessing a Y chromosome. Forty‐four patients were considered to belong to the syndrome of androgen insensitivity; 22 belonged to the syndrome of partial androgen insensitivity and 10 to the syndrome of testicular failure. No case of gonadal malignancy was found in the 44 patients with androgen insensitivity and one case of malignancy was found in the 22 with partial androgen insensitivity. Two cases of malignancy occurred in the ten patients with testicular failure. The relevance of these facts to the management of the problem of the female with a Y chromosome is discussed.