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ANTIBODIES TO TYPE 1 AND TYPE 2 HERPES VIRUS IN WOMEN WITH ABNORMAL CERVICAL CYTOLOGY
Author(s) -
Skinner Gordon R. B.,
Thouless Margaret E.,
Jordan Joseph A.
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00221.x
Subject(s) - medicine , virus , cervix , herpes virus , cytology , antibody , neutralizing antibody , genital herpes , carcinoma , virology , pathology , immunology , herpes simplex virus , cancer
Summary The sera of 335 women with normal and abnormal cervical cytology have been tested for neutralizing antibodies to type 1 and type 2 herpes virus. There were no significant differences between the mean k ‐values of any of the groups of patients against type 1 herpes virus. With type 2 virus, patients with histological evidence of cervical disease had significantly higher mean k ‐values than both the control gynaecological group and the control group of patients with genital carcinoma of other sites. This difference was independent of age and socio‐economic class. For patients with carcinoma in situ some preliminary evidence is presented suggesting that surgical conization of cervix results in a decline in type 2 herpes virus neutralizing antibody activity.