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CHEMOTHERAPY IN THE TREATMENT OF UNDELIVERED HYDATIDIFORM MOLE
Author(s) -
Ma H. K.,
Yip S. K.,
Chun Daphne
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00193.x
Subject(s) - molar pregnancy , in utero , uterus , molar , mole , degeneration (medical) , methotrexate , medicine , urinary system , chemotherapy , gynecology , pregnancy , surgery , pathology , fetus , gestation , biology , dentistry , genetics
Summary Methotrexate and 6‐mercaptopurine given to five cases of undelivered hydatidiform mole brought about degeneration of molar vesicles in utero , which was indicated by a fall in urinary gonadotrophin and a reduction in the size of the uterus. Spontaneous evacuation of the molar tissue occurred in three cases and artificial termination in two. All evacuated and surgical specimens showed various degrees of degeneration of the molar vesicles. In the last follow‐up 28 months later all five patients were alive and well with no evidence of trophoblastic disease.