Premium
AMNIOTIC FLUID UREA AND CREATININE IN NORMAL PREGNANCY AND IN PRE‐ECLAMPSIA
Author(s) -
Roopnarinesingh Syam,
Morris David
Publication year - 1971
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1971.tb00187.x
Subject(s) - creatinine , amniotic fluid , urea , eclampsia , gestation , pregnancy , renal function , placenta , medicine , endocrinology , obstetrics , fetus , chemistry , biology , biochemistry , genetics
Summary Urea and creatinine concentrations in the amniotic fluid and maternal blood were studied in normal and toxaemic mothers. There was a good correlation between liquor creatinine and duration of pregnancy, but a significant relationship between liquor urea and gestational age was not established. In pre‐eclampsia, levels of urea and creatinine in the amniotic fluid were significantly greater than normal values, at corresponding periods of gestation. These changes in the amniotic fluid were not accompanied by a similar increase in the maternal serum, and are consistent with the concept of a renal origin for this fluid. It is postulated that this trend in pre‐eclampsia reflects the inability of the placenta to fulfil its transfer function.