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SERUM PROTEIN CHANGES IN THE PRE‐ECLAMPSIA‐ECLAMPSIA SYNDROME
Author(s) -
Studd J. W. W.,
Blainey J. D.,
Bailey D. E.
Publication year - 1970
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1970.tb04401.x
Subject(s) - eclampsia , nephrotic syndrome , medicine , transferrin , albumin , blood proteins , endocrinology , glomerular basement membrane , proteinuria , glycoprotein , macroglobulin , chemistry , pregnancy , biology , biochemistry , kidney , genetics
Summary The technique of crossed antigen‐antibody immuno‐electrophoresis has been used to compare the serum protein changes of severe pre‐eclampsia with the changes of normal pregnancy. Decrease in the concentrations of serum albumin, transferrin and haemopexin and an increased concentration of α 1 glycoprotein, α 2 macroglobulin and β lipoprotein were found, giving a protein pattern essentially like that of the nephrotic syndrome. It is believed that these changes are a result of urinary loss of the proteins of intermediate molecular weight, with a compensatory unselective increased synthesis of protein in the liver, and retention in the serum of macroglobulins which are too large to pass through the defective glomerular basement membrane.