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CORRELATIONS BETWEEN HUMAN CHORIONIC SOMATO‐MAMMOTROPHIN (LACTOGEN), IMMUNOREACTIVE INSULIN, GLUCOSE AND LIPID FRACTIONS IN PLASMA OF PREGNANT WOMEN
Author(s) -
Fioretti P.,
Genazzani A. R.,
Aubert M. L.,
Gragnoli G.,
Pupillo A.
Publication year - 1970
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1970.tb03603.x
Subject(s) - endocrinology , medicine , insulin , hormone , pathogenesis , gestation , lipid metabolism , pregnancy , human placental lactogen , chemistry , metabolism , carbohydrate metabolism , fetus , biology , placenta , genetics
Summary The authors have assayed in 81 pregnancies, at various stages of gestation, the fasting values of plasma lipids, non‐esterified fatty acids, triglycerides, cholesterol, phospholipids, glucose and immunoreactive insulin, and have compared the findings with the values of immuno‐reactive human chorionic somato‐mammotropin assayed in the same women and in a further 31 pregnancies. On the bases of the results obtained and the biological activity of HCS, the importance of this hormonal peptide in the determination of the modifications of the metabolism of glucose and lipids is confirmed. The biological activities of HCS have also been compared with those of other hormonal factors which undergo particular increases in pregnancy (thyrotrophic, adrenocorticotrophic hormones and chorionic gonadotrophin). The pathogenesis of alterations in the glucoselipids metabolism of the pregnant women have been interpreted in the light of the glucose‐fatty‐acid cycle of Randle.