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TRANSFER OF LIMECYCLINE AND CEPHALORIDINE FROM MOTHER TO FETUS—A COMPARATIVE STUDY
Author(s) -
Prakash A.,
Chalmers J. A.,
Onojobi O. I. A.,
Henderson R. J.,
Cummings P.
Publication year - 1970
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1970.tb03515.x
Subject(s) - cephaloridine , amniotic fluid , fetus , antibiotics , medicine , obstetrics , umbilical cord , physiology , pregnancy , anesthesia , immunology , cephalosporin , biology , microbiology and biotechnology , genetics
Summary Limecycline was given by mouth 6‐hourly and cephaloridine was given intramuscularly 12‐hourly in two doses to 60 women undergoing amniotomy for induction of labour in order to study the absorption and transfer of the antibiotics to the fetus as a protection against intrapartum infections. Both drugs were shown to provide useful inhibitory concentrations in maternal serum, amniotic fluid and umbilical cord blood. The advantages and disadvantages of the two drugs, and the appropriate dose schemes for each antibiotic are discussed.