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Development of a low‐cost, industrially suitable medium for the production ofacetic acid from Clostridium thermoaceticum
Author(s) -
Bock Steven A.,
Fox Susan L.,
Gibbons William R.
Publication year - 1997
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1997.tb00423.x
Subject(s) - acetic acid , fermentation , chemistry , food science , ethanol fuel , pulp and paper industry , microbiology and biotechnology , biochemistry , biology , engineering
To develop a low‐cost, industrially suitable medium for acetic acid production from Clostridium thermo‐aceticum , two waste by‐products of corn ethanol production were evaluated as replacements for the most expensive ingredients in modified Ljungdahl's medium (MLM). Condensed corn solubles (CCS; 66.7 g/l dry matter) resulted in an acetate productivity (0.33 g/h per litre) equivalent to that in MLM during fed‐batch fermentation. Yields in CCS medium were often above the theoretical maximum owing to an unquantifiable substrate in the CCS. Although acetate concentrations in MLM were somewhat higher (35 g/l) than in CCS medium (32 g/l) it seems possible that further acclimation of the microbe could improve acetate production. CCS medium costs of $163/ton (1 U.S. ton = 907 kg) of calcium magnesium acetate (CMA) produced compare favourably with that of MLM ($6973/ton of CMA produced).