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Reversible binding of anthracycline antibiotics to erythrocytes treated with glutaraldehyde
Author(s) -
FI Ataullakhanov,
EV Kulikova,
VM Vitvitsky
Publication year - 1996
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1996.tb00401.x
Subject(s) - glutaraldehyde , antibiotics , daunorubicin , doxorubicin , incubation , anthracycline , microbiology and biotechnology , chemistry , pharmacology , biochemistry , biology , medicine , chemotherapy , chromatography , surgery , cancer , breast cancer
Human erythrocytes treated with glutaraldehyde can take up anthracycline antibiotics (daunorubicin and doxorubicin) from the incubation medium and do so faster than untreated cells. The antibiotics are readily released when the suspending medium is replaced with an antibiotic‐free one. Our findings provide evidence that glutaraldehyde‐treated erythrocytes remain capable of reversible binding of anthracycline antibiotics.