Premium
Comparative studies of recombinant human albumin and human serum albumin derived by blood fractionation
Author(s) -
Dodsworth N.,
Harris R.,
Denton K.,
Woodrow J.,
PC Wood,
Quirk A.
Publication year - 1996
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1996.tb00397.x
Subject(s) - recombinant dna , fractionation , albumin , human serum albumin , yeast , serum albumin , biochemistry , human albumin , chemistry , human blood , chromatography , saccharomyces cerevisiae , biology , physiology , gene
Recombinant human albumin produced in the yeast Saccharomyces cerevisial and human serum albumin derived from blood fractionation were compared by a series of analytical techniques. These demonstrated that the two proteins were equivalent structurally. However, differences observed in some of the assays indicated that the recombinant product had lower levels of structural heterogeneity than the blood‐derived protein.