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Syntheses and immunological effects of thymic humoral factor‐gamma 2 and its Phe7‐substituted analogues
Author(s) -
Abiko T.,
Sekino H.
Publication year - 1994
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1994.tb00302.x
Subject(s) - humoral immunity , immune system , immunology , antibody , biology , endocrinology , chemistry , medicine
Thymic humoral factor‐gamma 2 and five analogues modified at position 7 with various phenylalanine derivatives were synthesized by a solid‐phase method. The synthetic peptides were tested for their effects on the impaired blastogenic response of phytohaemagglutin‐stimulated T‐lymphocytes of uraemic patients with infectious diseases. The synthetic thymic humoral factor‐gamma 2 enhanced the blastogenic response of T‐lymphocytes in the blood of the two patients tested. Of the synthetic peptides, [4‐fluoro‐Phe7]thymic humoral factor‐gamma 2 exhibited the most potent effect.