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The amino aldehydes produced by spermine and spermidine oxidation with maize polyamine oxidase have anti‐leishmanial effect
Author(s) -
Cona A.,
Federico R.,
Gramiccia M.,
Orsini S.,
Gradoni L.
Publication year - 1991
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1991.tb00165.x
Subject(s) - spermidine , polyamine , spermine , polyamine oxidase , biochemistry , chemistry , autoxidation , oxidase test , enzyme
Purified maize polyamine oxidase bound to hydroxylapatite was utilized as an enzymatic reactor to produce oxidized spermidine and spermine. The oxidation products showed a consistent inhibitory activity on Leishmania infantum in mice. 1,3‐diaminopropane showed a much lower activity. Moreover chemically prepared 4‐aminobutyraldehyde had a similar ED50 to that of oxidized spermidine. It is concluded that among the compounds arising from polyamine oxidation those with the greatest anti‐leishmanial effect are 4‐aminobutyraldehyde and 1‐(3‐aminopropyl)‐4‐aminobutyraldehyde.