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Regulation of respiratory activity of brown adipose tissue mitochondria through changes in cytochromes
Author(s) -
Gaikwad A.,
Ramasarma T.,
Kurup CK
Publication year - 1990
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1990.tb00130.x
Subject(s) - brown adipose tissue , mitochondrion , cytochrome , respiratory system , respiration , adipose tissue , electron transport chain , cytochrome c , biology , chemistry , biochemistry , microbiology and biotechnology , enzyme , anatomy
Exposure of cold‐acclimatized rats to heat (37 degrees C) for a short period decreased brown adipose tissue (BAT) mitochondrial substrate‐dependent oxygen uptake and H2O2 generation. Both the concentration and substrate‐dependent rate of cytochrome b reduction decreased as early as 3 h of heat exposure. These results identify cytochrome b as the locus of regulation of electron transport in BAT mitochondria under conditions of heat stress.