Premium
Is there any role of membrane bilayer‐skeleton interaction in maintaining the transmembrane phospholipid asymmetry in erythrocytes?
Author(s) -
Gupta CM
Publication year - 1990
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1111/j.1470-8744.1990.tb00121.x
Subject(s) - phospholipid , transmembrane protein , bilayer , membrane , lipid bilayer , biophysics , phospholipid scramblase , skeleton (computer programming) , asymmetry , elasticity of cell membranes , chemistry , membrane protein , biological membrane , biochemistry , biology , lipid bilayer phase behavior , anatomy , receptor , physics , quantum mechanics , phosphatidylserine
Erythrocyte membrane phospholipids are asymmetrically distributed in two surfaces of the membrane bilayer. This asymmetry in these cells, on one hand, has been considered to arise from the membrane skeleton‐bilayer interactions, while on the other, it has been thought to originate from an ATP‐dependent aminophospholipid pump. A critical analysis of these two proposals, in the light of the existing literature, reveals that neither the membrane skeleton nor the aminophospholipid pump is adequate per se to maintain the phospholipid asymmetry. Instead, evidence is presented to show that the phospholipid pump together with the membrane skeleton is required for generation and maintenance of the transmembrane phospholipid asymmetry in native erythrocytes.