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Stimulation‐history effects on the M 100 revealed by its differential dependence on the stimulus onset interval
Author(s) -
Zacharias Norman,
König Reinhard,
Heil Peter
Publication year - 2012
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2012.01370.x
Subject(s) - n100 , magnetoencephalography , stimulus (psychology) , psychology , stimulation , neuroscience , interstimulus interval , electrophysiology , audiology , electroencephalography , cognitive psychology , event related potential , medicine
The amplitudes of the most prominent component of auditory evoked magnetic fields and electrical potentials, the M 100 and N 100, recorded from the human scalp depend on the duration of the stimulus onset interval ( SOI ). Here, we show, using magnetoencephalography, that the SOI dependence of the M 100 amplitude strongly depends upon whether stimuli with different SOIs are presented in a conventional block design or in a random manner. This differential dependence reveals that the M 100 is affected not only by the stimulus evoking it and by its predecessor, but by a longer‐term history of stimulation. We provide a parsimonious model that accounts for our findings with both designs in a quantitative manner. It assumes a transient, temporally asymmetric reduction in the excitability of a fraction of potentially excitable neurons. A rather stereotyped response function may therefore underlie the stimulation‐history effects in the human auditory cortex.