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Functional neural correlates of psychometric schizotypy: An fMRI study of antisaccades
Author(s) -
Aichert Désirée S.,
Williams Steven C.R.,
Möller HansJürgen,
Kumari Veena,
Ettinger Ulrich
Publication year - 2012
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2011.01306.x
Subject(s) - schizotypy , psychology , neurocognitive , schizophrenia (object oriented programming) , psychosis , neuroscience , functional magnetic resonance imaging , intraparietal sulcus , cognition , antisaccade task , audiology , prefrontal cortex , saccade , developmental psychology , eye movement , psychiatry , medicine
Dimensional models of psychosis assume a continuum between schizotypy and schizophrenia. However, little is known about the overlap in brain functional alterations between schizotypy and schizophrenia. Fifty‐four healthy volunteers underwent functional magnetic resonance imaging during an antisaccade task, a measure of cognitive control known to be impaired in schizophrenia, and a prosaccade task. Higher positive schizotypy was correlated with higher antisaccade error rates. Associations between reduced blood oxygenation level dependent signal and higher schizotypy were found during antisaccades in the putamen, thalamus, cerebellum, and visual cortex and during prosaccades in the visual cortex, supplementary eye field, and posterior intraparietal sulcus. These findings show that increased schizotypy is associated with decreased antisaccade performance and reduced brain function in regions also affected in schizophrenia, therefore providing evidence of neurocognitive and neurophysiological overlap between schizotypy and schizophrenia.