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Neural response to the second stimulus associated with poor speed discrimination performance in schizophrenia
Author(s) -
Wang Jun,
Dobkins Karen R.,
McDowell Jennifer E.,
Clementz Brett A.
Publication year - 2012
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2011.01302.x
Subject(s) - psychology , stimulus (psychology) , extrastriate cortex , neuroscience , audiology , cognition , neural correlates of consciousness , visual cortex , visual processing , electroencephalography , cognitive psychology , perception , medicine
Visual motion processing is compromised in schizophrenia ( SZ ), but it is uncertain what neural deviations account for their motion analysis abnormalities. Neural activations were measured with dense‐array electroencephalography while 14 medicated SZ and 14 healthy persons performed a paired‐stimuli forced choice speed discrimination task. SZ had (a) worse‐at‐speed discrimination, replicating previous findings, (b) normal early extrastriate neural activity ( N 1) to both motion stimuli, (c) reduced later extrastriate activity ( P 2) specifically to the second stimulus, and (d) following P 2, an enhanced later N 2 over parietal cortex. Stronger P 2 and N 2 responses were associated with better speed discrimination performance across groups. These findings indicate that the neural correlates of poor motion analysis in SZ may not be an early visual analysis abnormality but a problem with efficient use of speed information later in cognitive processing.