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Beta‐adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults
Author(s) -
Kelsey Robert M.,
Alpert Bruce S.,
Dahmer Mary K.,
Krushkal Julia,
Quasney Michael W.
Publication year - 2010
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2010.01006.x
Subject(s) - blood pressure , heart rate , reactivity (psychology) , polymorphism (computer science) , medicine , receptor , psychology , adrenergic receptor , young adult , endocrinology , gene , allele , genetics , biology , alternative medicine , pathology
Cardiovascular reactivity to stress and β‐adrenergic receptor (β‐AR) function may contribute to the development of hypertension. As Black Americans have an increased risk of hypertension, we evaluated associations between β 1 ‐AR (Arg389Gly) and β 2 ‐AR (Arg16Gly, Gln27Glu) gene variants and cardiovascular reactivity in 500 Black youth. Heart rate, preejection period, total peripheral resistance, and blood pressure reactivity were measured during cold and psychological stress. The Arg389Gly polymorphism in the β 1 ‐AR was associated with preejection period reactivity in males but not in females. The Arg16Gly polymorphism in the β 2 ‐AR was associated with diastolic blood pressure reactivity only during video game stress. An association between the Gln27Glu polymorphism in the β 2 ‐AR and vascular reactivity depended on sex. Thus, specific patterns of associations emerged between genetic variations in β‐ARs and cardiovascular reactivity in young Blacks.