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Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects
Author(s) -
Takahashi Hidetoshi,
Iwase Masao,
Canuet Leonides,
Yasuda Yuka,
Ohi Kazutaka,
Fukumoto Motoyuki,
Iike Naomi,
Nakahachi Takayuki,
Ikezawa Koji,
Azechi Michiyo,
Kurimoto Ryu,
Ishii Ryouhei,
Yoshida Tetsuhiko,
Kazui Hiroaki,
Hashimoto Ryota,
Takeda Masatoshi
Publication year - 2010
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2010.01000.x
Subject(s) - schizotypy , prepulse inhibition , psychology , acoustic startle reflex , audiology , moro reflex , startle response , sensory gating , developmental psychology , trait , schizophrenia (object oriented programming) , cognition , gating , reflex , neuroscience , psychiatry , medicine , computer science , programming language
Prepulse inhibition (PPI) of the acoustic startle reflex (ASR) is the most common psychophysiological index of sensorimotor gating. Several studies have investigated the relationship of PPI of ASR to schizotypy in Caucasians. However, little has been reported on this relationship in Asians. We investigated a possible relationship between PPI of ASR and schizotypy in 79 healthy Japanese subjects. Schizotypy was assessed by the Schizotypal personality Questionnaire (SPQ). PPI was evaluated at signal‐to‐noise ratios (SnRs: difference between background noise intensity and prepulse intensity) of +12, +16, and +20 dB. The total SPQ score, cognitive/perceptual score, and interpersonal score correlated negatively with PPI at SnR of +16 and +20 dB. We conclude that PPI is associated with the trait of schizotypy in healthy Asian subjects.