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Measurement of mismatch negativity in individuals: A study using single‐trial analysis
Author(s) -
Bishop D. V. M.,
Hardiman M. J.
Publication year - 2010
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2009.00970.x
Subject(s) - mismatch negativity , psychology , audiology , set (abstract data type) , analysis of variance , electroencephalography , statistics , neuroscience , mathematics , medicine , computer science , programming language
Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial‐by‐trial variance are first removed. Next, each deviant response has the preceding standard response subtracted, giving a set of single trial difference waves. We illustrate this approach in analysis of MMN to brief tones in 17 adults. The best criterion for MMN combined t ‐test with an index of inter‐trial coherence, giving significant MMN in 14 (82%) of individuals. Single‐trial methods can indicate which people show MMN. However, in some clinically normal individuals there was no MMN, despite good behavioral discrimination of stimuli.