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AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle‐aged European‐Americans
Author(s) -
Neumann Serina A.,
Tingley Whittemore G.,
Conklin Bruce R.,
Shrader Catherine J.,
Peet Eloise,
Muldoon Matthew F.,
Jennings J. Richard,
Ferrell Robert E.,
Manuck Stephen B.
Publication year - 2009
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2009.00802.x
Subject(s) - heart rate variability , heart rate , medicine , psychology , resting heart rate , polymorphism (computer science) , autonomic nervous system , cardiology , allele , blood pressure , biology , genetics , gene
Previous evidence suggests that the dual‐specific A kinase‐anchoring protein 2 functional polymorphism (AKAP10 (A/G) I646V) influences heart rate (HR) and heart rate variability (HRV) in mice and humans ( N =122) with cardiovascular disease. Here, we asked whether this AKAP10 variant predicts HR and HRV in a large sample of healthy humans. Resting HR and short‐term time and frequency domain measures of HRV (5 min during paced and unpaced respiration conditions) were assessed in a U.S. community sample ( N =1,033) of generally healthy men and women (age 30–54) of European ancestry. Each person was genotyped for the AKAP10 variant. As with previous work, the AKAP10 Val allele predicted greater resting HR (Paced p <.01; Unpaced p <.03) and diminished HRV (Paced p s <.05) suggesting that this variant may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death.