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Superior temporal gyrus spectral abnormalities in schizophrenia
Author(s) -
Edgar J. Christopher,
Hanlon Faith M.,
Huang MingXiong,
Weisend Michael P.,
Thoma Robert J.,
Carpenter Bruce,
Hoechstetter Karsten,
Cañive José M.,
Miller Gregory A.
Publication year - 2008
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2008.00682.x
Subject(s) - magnetoencephalography , psychology , audiology , lateralization of brain function , stimulus (psychology) , neuroscience , superior temporal gyrus , schizophrenia (object oriented programming) , laterality , electroencephalography , electrophysiology , functional magnetic resonance imaging , cognitive psychology , psychiatry , medicine
Considerable evidence indicates early auditory stimulus processing abnormalities in schizophrenia, but the mechanisms are unclear. The present study examined oscillatory phenomena during a paired‐click paradigm in the superior temporal gyrus (STG) as a possible core problem. The primary question addressed is whether first click and/or second click group differences in the time‐domain evoked response in patients with schizophrenia are due to (1) group differences in the magnitude of poststimulus oscillatory activity, (2) group differences in poststimulus phase‐locking, and/or (3) group differences in the magnitude of ongoing background oscillatory activity. Dense‐array magnetoencephalography from 45 controls and 45 patients with schizophrenia produced left‐ and right‐hemisphere STG 50‐ and 100‐ms time‐frequency evoked, phase‐locking, and total power measures. Whereas first click 100‐ms evoked theta and alpha abnormalities were observed bilaterally, evoked low beta‐band differences were specific to the left hemisphere. Compared to controls, patients with schizophrenia showed more low‐frequency phase variability, and the decreased 100‐ms S1 evoked response observed in patients was best predicted by the STG phase‐locking measure.