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Heritability of frontal brain function related to action monitoring
Author(s) -
Anokhin Andrey P.,
Golosheykin Simon,
Heath Andrew C.
Publication year - 2008
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2008.00664.x
Subject(s) - psychology , endophenotype , error related negativity , anterior cingulate cortex , heritability , negativity effect , developmental psychology , action (physics) , electroencephalography , behavioural genetics , psychopathology , cognitive psychology , dizygotic twins , neural correlates of consciousness , neuroscience , cognition , clinical psychology , evolutionary biology , biology , physics , quantum mechanics , medicine , obstetrics
Monitoring the correspondence between the intended and actually executed action, a fundamental mechanism of behavioral regulation, is reflected by error‐related negativity (ERN), an ERP component generated by the anterior cingulate cortex. This study examined genetic influences on the ERN and other components related to action monitoring (correct negativity, CRN, and error positivity, P e ). A flanker task was administered to adolescent twins (age 12) including 99 monozygotic (MZ) and 175 dizygotic (DZ) pairs. Genetic analysis showed substantial heritability of all three ERP components (40%–60%) and significant genetic correlations between them. This study provides the first evidence for heritable individual differences in the neural substrates of action monitoring and suggests that ERN, CRN, and P e can potentially serve as endophenotypes for genetic studies of personality traits and psychopathology associated with abnormal regulation of behavior.