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Electrophysiological correlates of response inhibition in children and adolescents with ADHD: Influence of gender, age, and previous treatment history
Author(s) -
Liotti Mario,
Pliszka Steven R.,
Perez Ricardo,
Luus Brian,
Glahn David,
SemrudClikeman Margaret
Publication year - 2007
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.2007.00568.x
Subject(s) - psychology , response inhibition , audiology , electrophysiology , scalp , developmental psychology , cognition , electroencephalography , dorsolateral prefrontal cortex , prefrontal cortex , attention deficit hyperactivity disorder , event related potential , brain activity and meditation , neuroscience , clinical psychology , medicine , anatomy
Deficits in response inhibition may be at the core of the cognitive syndrome in ADHD. Here, inhibitory control mechanisms were studied in 36 ADHD‐combined type and 30 healthy children by exploring the event‐related brain activity during the Stop Signal task. The influence of age, gender, and previous treatment history was evaluated. The ADHD group showed reduced N200 wave amplitudes. For successful inhibitions, the N200 reduction was greatest over right inferior frontal scalp, and only the control group showed a success‐related enhancement of such right frontal N200. Source analysis identified a source of the N200 group effect in right dorsolateral prefrontal cortex. Finally, a late positive wave to failed inhibitions was selectively reduced only in treatment‐naïve ADHD children, suggesting that chronic stimulants may normalize late conscious error recognition. Both effects were independent of gender and age.