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Brain event‐related potentials to complex tones in depressed patients: Relations to perceptual asymmetry and clinical features
Author(s) -
BRUDER GERARD E.,
TENKE CRAIG E.,
STEWART JONATHAN W.,
TOWEY JAMES P.,
LEITE PAUL,
VOGLMAIER MARTINA,
QUITKIN FREDERIC M.
Publication year - 1995
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.1995.tb01220.x
Subject(s) - dichotic listening , psychology , audiology , asymmetry , brain asymmetry , perception , event related potential , cognition , laterality , tone (literature) , developmental psychology , neuroscience , lateralization of brain function , medicine , art , physics , literature , quantum mechanics
Brain event‐related potentials (ERPs) to probe tones in a dichotic complex tone test were recorded from right‐handed depressed patients ( n = 44) and normal subjects ( n = 19) at homologous sites over left and right hemispheres (F3, F4; C3, C4; P3, P4; O1, O2). There were no differences between groups in N1 or P2 amplitude, but patients had smaller P3 amplitude than did normal subjects. Depressed patients failed to show either the left ear advantage or behavior‐related hemispheric asymmetry of P3 seen for normal subjects. Depressed patients also showed less differences in hemispheric asymmetry between same and different judgments. These findings indicate that the abnormal behavioral asymmetry for dichotic pitch discrimination in depressed patients reflects a reduction in hemispheric asymmetry and is related to relatively late stages of cognitive processing.