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The Relationship of Symptomatology and Medication to Electrodermal Activity in Schizophrenia
Author(s) -
Green Michael Foster,
Nuechterlein Keith H.,
Satz Paul
Publication year - 1989
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.1989.tb03147.x
Subject(s) - anticholinergic , psychology , skin conductance , tonic (physiology) , psychosis , clinical psychology , audiology , psychiatry , medicine , neuroscience , biomedical engineering
An electrodermal assessment procedure using mild innocuous tones, task‐relevant tones, and loud white noise was administered to a sample of schizophernic patients (n=77). The present study investigated the relationship of schizophrenic symptomatology and anticholinergic level of neuroleptic medication to electrodermal variables. Each patient was evaluated for positive (florid) and negative (defect) symptoms. The neuroleptics that patients received were rated according to their anticholinergic effect. No significant differences in symptomatology were observed between electrodermal responders and nonresponders; however, nonresponders showed a nonsignificant tendency to have more positive and negative symptoms than responders. Both negative symptoms and anticholinergic levels were significant predictors of lower tonic levels of skin conductance. Patients receiving high anticholinergic neuroleptics showed significantly reduced measures of electrodermal responsivity and tonic levels. Thus, both symptomatology and type of neuroleptic are related to electrodermal measures, with the anticholinergic effect of neuroleptic medication being more pronounced.