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Influence of Neuromuscular Blocking Drugs on Recovery of Skeletal Electromyographic Activity in the Rat
Author(s) -
Wilson J. Roger,
Dicara Leo V.
Publication year - 1975
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.1975.tb01285.x
Subject(s) - biceps , paralysis , electromyography , anesthesia , psychology , neuromuscular blocking agents , medicine , physical medicine and rehabilitation , neuroscience , psychiatry
Dose‐related from muscular paralysis was examined in rats following a single intraperitoneal injection of one of three neuromuscular blockers: succinylcholine (SC), dimethyl d‐tubocurarine iodide (DM), or d‐tubocurarine chloride (dTC), Electromyographic (EMG) activity of the ipsilateral biceps femoris and biceps brachii muscles were sampled in each S. Time required to attain a predetermined percent integrated EMG activity, relative in a level established after drug stabilization, served as the major index of recovery. The results showed that the effect of SC and DM on regaining motor control is predictable on a mg/kg body weight basis. However, increasing the dose level of dTC produced no difference in the time required for the initial consistent signs of EMG recovery. Drug‐dosage effects on recovery from paralysis could not be attributed to systematic changes in either basal heart rate or rectal temperature. The results are interpreted as supporting other reports of the unpredictable consequences of dTC‐induced paralysis.