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The Effect of Artificial Ventilation on Cardiovascular Status and on Heart Rate Conditioning in the Curarized Rat
Author(s) -
Middaugh Susan,
Eissenberg Ethel,
Brener Jasper
Publication year - 1975
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/j.1469-8986.1975.tb00040.x
Subject(s) - heart rate , blood pressure , ventilation (architecture) , anesthesia , conditioning , respiratory system , respiratory rate , psychology , medicine , mechanical engineering , statistics , mathematics , engineering
The relationship between artificial ventilation, cardiovascular status, and operant conditioning in the curarized rat was investigated in a series of studies. Two respiratory parameters, peak inspiratory pressure (PIP) and respiratory rate (RR), were sequentially altered in curarized rats while heart rate and variability, and mean blood pressure were recorded. Heart rate increases or decreases were also rewarded in curarized rats ventilated at differing PIP values, 20 cm H2O or 12 cm H2O. Heart rate and variability were also recorded in non‐curarized rats. At PIP 12, heart rate and variability in the curarized rat was very similar to that of the non‐curarized rat. These subjects responded to operant contingencies. Subjects ventilated at PIP 20, however, showed elevated, invariant, and unresponsive heart rates. Ventilation therefore, proved an important determinant of cardiovasculur status and conditionability in the curarized rat. RR was not related to heart rate or variability. Neither PIP nor RR affected blood pressure.