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The clinical spectrum of the m.10191T>C mutation in complex I‐deficient Leigh syndrome
Author(s) -
NESBITT VICTORIA,
MORRISON PATRICK J,
CRUSHELL ELLEN,
DONNELLY DEIRDRE E,
ALSTON CHARLOTTE L,
HE LANGPING,
MCFARLAND ROBERT,
TAYLOR ROBERT W
Publication year - 2012
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2012.04224.x
Subject(s) - leigh disease , mutation , mitochondrial dna , mitochondrial disease , genetics , point mutation , mitochondrial respiratory chain , respiratory chain , genetic heterogeneity , genetic counseling , biology , disease , medicine , gene , bioinformatics , mitochondrion , phenotype
Mitochondrial respiratory chain diseases represent one of the most common inherited neurometabolic disorders of childhood, affecting a minimum of 1 in 7500 live births. The marked clinical, biochemical, and genetic heterogeneity means that accurate genetic counselling relies heavily upon the identification of the underlying causative mutation in the individual and determination of carrier status in the parents. Isolated complex I deficiency is the most common respiratory chain defect observed in children, resulting in organ‐specific or multisystem disease, but most often presenting as Leigh syndrome, for which mitochondrial DNA mutations are important causes. Several recurrent, pathogenic point mutations in the MTND3 gene – including m.10191T>C ( p .Ser45Pro) – have been previously identified. In this short clinical review we evaluate the case reports of the m.10191T>C mutation causing complex I‐deficient Leigh syndrome described in the literature, in addition to two new ones diagnosed in our laboratory. Both of these appear to have arisen de novo without transmission of the mutation from mother to offspring, illustrating the importance not only of fully characterizing the mitochondrial genome as part of the investigation of children with complex I‐deficient Leigh syndrome but also of assessing maternal samples to provide crucial genetic advice for families.