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Short‐ and long‐term outcome of patients with symptoms of spinal cord compression by neuroblastoma
Author(s) -
SIMON THORSTEN,
NIEMANN CATHERINA ANNIKA,
HERO BARBARA,
HENZE GÜNTHER,
SUTTORP MEINOLF,
SCHILLING FREIMUT H,
BERTHOLD FRANK
Publication year - 2012
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2012.04219.x
Subject(s) - spinal cord compression , neuroblastoma , term (time) , outcome (game theory) , spinal cord , medicine , pediatrics , psychiatry , biology , economics , genetics , cell culture , physics , mathematical economics , quantum mechanics
Aim Prospective trials on neuroblastoma‐induced myelopathy are lacking. Therefore, we retrospectively analysed patients in four national neuroblastoma trials. Method Neuroblastoma patients diagnosed between August 1989 and December 2008 were included. Clinical and molecular data were available in the national trials database. Additional details on neurological findings, treatment, and outcome were collected using a questionnaire. Results Among 2603 patients, 122 (61 males and 61 females) had symptoms of spinal cord compression (SCC), and 99 of these were included in the final long‐term analysis. The survival of patients with symptoms of SCC was better than that of patients without symptoms. Patients first presented with lower extremity motor impairment (95%), impaired cutaneous sensibility (58%), neuropathic pain (56%), bladder dysfunction (44%), and/or constipation (34%). Symptoms improved after first‐line neurosurgery in 36 out of 52 patients and after first line chemotherapy in 30 out of 47 patients ( p =0.77). After a median observation time of 8 years 1 month (range 1mo–19y 6mo), 71 out of 99 patients still had residual impairments: motor impairment (43%), scoliosis (31%), impaired bladder function (26%), constipation (19%), impaired cutaneous sensibility (17%), growth delay (14%), and neuropathic pain (5%). The initial treatment had no clear impact on the frequency of late effects. Interpretation This retrospective analysis showed no clear advantage of either first‐line neurosurgery or chemotherapy and that most patients still exhibit residual symptoms and require specialized care.