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Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder
Author(s) -
RODRIGUES MASRUHA MARCELO,
LIN JAIME,
ARITA JULIANA HARUMI,
DE CASTRO NETO EDUARDO FERREIRA,
SCERNI DÉBORA AMADO,
CAVALHEIRO ESPER ABRÃO,
MAZZACORATTI MARIA DA GRAÇA NAFFAH,
VILANOVA LUIZ CELSO PEREIRA
Publication year - 2011
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2010.03854.x
Subject(s) - agenesis of the corpus callosum , hypothermia , corpus callosum , anesthesia , neurotransmitter , medicine , hyperhidrosis , hyperthermia , psychology , neuroscience , central nervous system
Spontaneous periodic episodes of hypothermia still defy medical knowledge. In 1969, Shapiro et al. described the first two cases of spontaneous periodic hypothermia associated with agenesis of the corpus callosum. Recently, Dundar et al. reported a case of spontaneous periodic hypothermia and hyperhidrosis without corpus callosum agenesis, suggesting that the periodic episodes of hypothermia might be of epileptiform origin. Here we describe two paediatric patients with spontaneous periodic hypothermia without corpus callosum agenesis and demonstrate, to our knowledge for the first time, altered levels of neurotransmitter metabolites within the cerebrospinal fluid.