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Cerebral sinus venous thrombosis in Swiss children
Author(s) -
GRUNT SEBASTIAN,
WINGEIER KEVIN,
WEHRLI EDITH,
BOLTSHAUSER EUGEN,
CAPONE ANDREA,
FLUSS JOEL,
GUBSERMERCATI DANIELLE,
JEANNET PIERREYVES,
KELLER ELMAR,
MARCOZ JEANPIERRE,
SCHMITTMECHELKE THOMAS,
WEBER PETER,
WEISSERT MARKUS,
STEINLIN MAJA
Publication year - 2010
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2010.03722.x
Subject(s) - medicine , pediatrics , confidence interval , odds ratio , incidence (geometry) , venous thrombosis , neuropsychology , thrombosis , cognition , surgery , physics , psychiatry , optics
Aim To describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) in Switzerland. Method Data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow‐up examination and a cognitive assessment were performed (mean follow‐up period 26mo). Differences between neonates and children (patients older than 28d) were assessed and predictors of outcome were determined. Results Twenty‐one neonates (14 males, seven females; mean age 9d, SD 8d) and 44 children (30 males, 14 females; mean age 8y 7mo, SD 4y 5mo) were reported. The incidence of paediatric CSVT in Switzerland was 0.558 per 100 000 per year. In neonates, the deep venous system was more often involved and parenchymal injuries were more common. The strongest predictor of poor outcome was neonatal age (odds ratio 17.8, 95% confidence interval 0.847–372.353). Most children showed global cognitive abilities within the normal range, but impairments in single cognitive subdomains were frequent. Interpretation Paediatric CSVT is rare. Its outcome is poor in neonates. Most children have good neurological outcomes, but some patients have individual neuropsychological impairments.