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Cerebral palsy and assisted reproductive technologies: a case–control study
Author(s) -
REID SUSAN M,
JAQUES ALICE M,
SUSANTO CYNTHIA,
BREHENY SUSAN,
REDDIHOUGH DINAH S,
HALLIDAY JANE
Publication year - 2010
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2009.03556.x
Subject(s) - odds ratio , cerebral palsy , confidence interval , gestational age , gross motor function classification system , medicine , spastic , logistic regression , birth weight , obstetrics , pediatrics , pregnancy , gynecology , biology , physical therapy , genetics
Aim To determine whether assisted reproductive technologies (ART) were more likely to be the method of conception in singletons with cerebral palsy (CP) than in those without CP. Method Singletons with CP born between 1991 and 2004 were selected from the Victorian Cerebral Palsy Register and matched for birth year to two singletons randomly selected from the Victorian Perinatal Data Collection Unit. Data from both sources were linked to records from three ART centres. Conditional logistic regression was used to assess the association between CP and aspects of conception using ART. Multivariate models were adjusted for parity, previous miscarriages, sex, gestational age, birthweight, and weight for gestational age. Results We identified 1241 singletons with CP (males n= 721 [58%], females n= 420 [42/100]; motor type: spastic [87%; unilateral 37%; bilateral 63%], ataxic n= 60 [5/100], dyskinetic n= 46 [4/100], hypotonic n= 29 [2/100], unknown n= 25 [2/100]. Gross Motor Function Classification System levels were I n =363 [29/100], II n =297 [24/100], III n =137 [11/100], IV n =160 [13/100], V n= 192 [15/100], and unknown n =92 [7/100]). Sixteen (1.3/100) of the children with CP and 25 (1.0/100) of 2482 children without CP were conceived using ART. There was no significant increase in the odds of children with CP being conceived using ART (adjusted odds ratio 1.19, 95% confidence interval (CI) 0.63, 2.24) nor in the odds of them being conceived by a subfertile couple without ART (adjusted odds ratio 2.7, 95% CI 0.87, 8.36). Interpretation Singleton conception using ART is not strongly associated with an increased risk of CP.