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Malignant migrating partial seizures in Aicardi syndrome
Author(s) -
JocicJakubi Bosanka,
Lagae Lieven
Publication year - 2008
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2008.03091.x
Subject(s) - epilepsy , corpus callosum , partial seizures , medicine , pediatrics , tonic (physiology) , ictal , psychology , psychomotor learning , seizure types , psychomotor retardation , microcephaly , complex partial seizures , anesthesia , neuroscience , temporal lobe , pathology , cognition , alternative medicine
This article reports on a female infant with Aicardi syndrome presenting with malignant migrating partial seizures from her first day of life. Initially, unilateral tonic seizures were seen with contralateral ictal electroencephalogram findings. Typically, these tonic seizures were accompanied by head and eye deviation and were followed by a tonic seizure on the other side of the body. At 6 months of age she developed epileptic spasms. She showed no motor development, did not respond to eye contact, and was nasogastric tube‐fed. The epilepsy syndrome in this child is refractory to antiepileptic treatment and there is no psychomotor development. This case expands the phenotype of this catastrophic epileptic encephalopathy and suggests that the corpus callosum is not necessary for the ‘migration’ of partial seizures in this syndrome.