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Bronchopulmonary dysplasia predicts adverse developmental and clinical outcomes in very‐low‐birthweight infants
Author(s) -
Jeng SuhFang,
Hsu ChyongHsin,
Tsao PoNien,
Chou HungChieh,
Lee WangTso,
Kao HsinAn,
Hung HanYang,
Chang JuiHsing,
Chiu NanChang,
Hsieh WuShiun
Publication year - 2008
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2007.02011.x
Subject(s) - bronchopulmonary dysplasia , medicine , pediatrics , bayley scales of infant development , gestational age , low birth weight , toddler , birth weight , pregnancy , psychology , psychiatry , cognition , developmental psychology , genetics , biology , psychomotor learning
This study examined the developmental and clinical outcomes in very‐low‐birthweight (VLBW; ≤1500g) infants with and without bronchopulmonary dysplasia (BPD) throughout infancy, and assessed if BPD predicted poor developmental outcome beyond the effects of other risk factors. One hundred and three VLBW infants (53 males, 50 females; mean gestational age 28wks [SD 2] birthweight 1041g [SD 261]) were graded for severity of BPD according to the American National Institutes of Health (NIH) consensus definition. Neuro‐development was assessed using the Neonatal Neurobehavioral Examination‐Chinese version, at 36 and 39 weeks' postmenstrual age, and the 2nd edition of the Bayley Scales of Infant Development at 6 and 12 months' corrected age. Clinical outcome was measured by means of rehospitalization for pulmonary causes and treatment with pulmonary medications. Compared with infants without BPD, infants with BPD had higher rates of clinical morbidity, and those with severe BPD further exhibited higher incidences of developmental delay throughout infancy. BPD predicts poor 1‐year developmental and clinical outcomes in VLBW infants for which effects are well correlated to the NIH consensus definition.