Premium
Acute bilateral striatal necrosis with rotavirus gastroenteritis and inborn metabolic predisposition
Author(s) -
Mordekar Santosh,
Jaspan Tim,
Sharrard Mark,
Morton Richard,
Whitehouse William P
Publication year - 2005
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2005.tb01163.x
Subject(s) - rotavirus , encephalopathy , medicine , necrosis , encephalitis , gastroenterology , excretion , magnetic resonance imaging , pediatrics , rotavirus gastroenteritis , pathology , diarrhea , immunology , radiology , virus
We present a 9‐month‐old male with acute rotavirus gastroenteritis who developed an acute encephalopathy with focal seizures and developmental regression. Magnetic resonance imaging showed bilateral striatal necrosis and raised glutarylcarnitine levels on tandem mass spectrometry of a (crisis) blood spot, and chromatography of organic acids revealed increased urinary excretion of dicarboxylic acid. Skin biopsy demonstrated a partial decrease in glutaryl‐CoA dehydrogenase activity. The case was not typical for either rotavirus encephalitis/rotavirus‐associated encephalopathy or for glutaric aciduria type I. The patient has developmental delay and continues to receive physiotherapy, speech therapy, and local developmental follow‐up.