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Cognitive competence at the onset of West syndrome: correlation with EEG patterns and visual function
Author(s) -
Randò Teresa,
Baranello Giovanni,
Ricci Daniela,
Guzzetta Andrea,
Tinelli Francesca,
Biagioni Enrico,
La Torre Giuseppe,
Epifanio Roberta,
Signorini Sabrina,
Fazzi Elisa,
Mercuri Eugenio,
Cioni Giovanni,
Guzzetta Francesco
Publication year - 2005
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2005.tb01074.x
Subject(s) - cognition , electroencephalography , audiology , psychology , hypsarrhythmia , neuroimaging , developmental psychology , medicine , psychiatry
The aim of this study was to evaluate cognitive development at the onset of West syndrome (WS) with regard to electroencephalogram (EEG) patterns and visual function. Twenty‐five patients (14 males, 11 females) at the onset of spasms ( T 0 ) in WS and 2 months later ( T 1 ) underwent a full clinical evaluation, including neuroimaging, cognitive assessment, video‐EEG, and visual function. Mean age of the patients at spasm onset was 5.9 months (SD 2.5; range 2 to 13mo). Cognitive development, assessed with Griffiths Mental Development Scales (GMDS), was generally impaired at T 0 and was significantly related to visual function ( p <0.001) at both T 0 and T 1 In general, there was a specific major impairment in the eye–hand coordination scale of the GMDS which tended to disappear after 2 months in less severe cases. At the onset of spasms, sleep EEG organization seemed to be better related to cognitive abilities than awake hypsarrhythmia. These results support a close link between visual function and cognitive competence in WS and provide additional information to improve the understanding of possible mechanisms underlying cognitive impairment.