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Is treatment with growth hormone effective in children with cerebral palsy?
Author(s) -
Shim Melanie L,
Moshang Thomas,
Oppenheim William L,
Cohen Pinchas
Publication year - 2004
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2004.tb01016.x
Subject(s) - cerebral palsy , growth hormone deficiency , short stature , growth hormone , linear growth , medicine , growth retardation , pediatrics , endocrinology , hormone , pregnancy , biology , physical therapy , mathematics , genetics
Children with cerebral palsy (CP) often have poor linear growth during childhood, resulting in a diminished final adult height. Here we report a female with CP and short stature but without growth hormone (GH) deficiency who exhibited increased growth during treatment with GH. We also report two other children with CP who were treated with GH: one female with a history of leukemia, and a male with Klinefelter syndrome. These two children were both found to be GH‐deficient by insulin provocative GH testing and responded to treatment with increased growth rate. Growth improved to a greater extent in the two children with apparent GH deficiency. In summary, it is felt that GH therapy might be beneficial for children with CP and warrants further investigation.