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Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes
Author(s) -
Baglietto Maria Giuseppina,
Battaglia Francesca Maria,
Nobili Lino,
Tortorelli Silvia,
Negri Emanuela De,
Calevo Maria Grazia,
Veneselli Edvige
Publication year - 2001
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2001.tb00229.x
Subject(s) - rolandic epilepsy , psychology , audiology , ictal , neuropsychology , neuropsychological test , epilepsy , verbal fluency test , boston naming test , trail making test , cognition , developmental psychology , psychiatry , medicine
Nine children (five males, four females; age range 6 years 1 month to 11 years 1 month) affected by benign epilepsy of childhood with centrotemporal or Rolandic spikes (BECRS) with EEG evidence of marked activation of interictal epileptic discharges (IEDs) during sleep, and nine unaffected control children matched for age, sex, and socioeconomic status, were enrolled in a prospective study. At the time of detection of IED activation during sleep, patients showed a mean Full‐Scale IQ score within the normal range, but significantly below that of control participants; neuropsychological assessment revealed disorders in visuospatial short‐term memory (Corsi's Block Tapping Test), attention, and cognitive flexibility (Trail Making Test and Stroop Color‐Word Test), picture naming, and fluency (Benton's Naming Test and Word Fluency), visuoperceptual skill (Ghent‐Poppelreuter and Street Gestalt Completion Tests) and visuomotor coordination (Bender Test). After detection of IED activation during sleep, children were followed up for 2 years. At the time of IED remission (T1), neuropsychological re‐evaluation showed a notable increase in IQ score and a significant improvement ( t ‐test: p <0.007) in visuomotor coordination, non‐verbal short‐term memory, sustained attention and mental flexibility, picture naming, and visual‐perceptual performance. At T1, patients’performance did not differ from the controls (Mann‐Whitney U test).