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Effectiveness of lamotrigine in children with paroxysmal kinesigenic choreoathetosis
Author(s) -
Überall Michael A,
Wenzel Dieter
Publication year - 2000
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.2000.tb00682.x
Subject(s) - lamotrigine , medicine , paroxysmal dyskinesia , choreoathetosis , pediatrics , psychiatry , epilepsy , dyskinesia , dystonia , disease , parkinson's disease
Paroxysmal kinesigenic choreoathetosis (PKC) is a rare movement disorder, characterized by recurrent, brief involuntary dystonic attacks that are provoked by sudden movements. Pathophysiology is uncertain, but a channelopathy is discussed. Treatment recommendations favour antiepileptic drugs (AEDs) acting on voltage‐gated neuronal ion channels. This report summarizes the history of three children (6, 8, and 10 years of age) with idiopathic PKC successfully treated with low doses of lamotrigine, an AED acting primarily via neuronal voltage‐sensitive sodium channels.