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Is ACTH a key to understanding anticonvulsant action?
Author(s) -
O'Regan ME,
DCH JK Brown MB FRCP
Publication year - 1998
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.1998.tb15366.x
Subject(s) - anticonvulsant , adrenocorticotropic hormone , action (physics) , benzodiazepine , electroencephalography , anticonvulsant drugs , medicine , mechanism of action , pharmacology , psychology , epilepsy , endocrinology , neuroscience , hormone , chemistry , receptor , biochemistry , physics , quantum mechanics , in vitro
Adrenocorticotrophin hormone (ACTH) has been used as an anticonvulsant for many years. In this paper, the use of ACTH in 23 children with intractable epilepsies is described. It was found that ACTH worked most effectively when the EEG showed benzodiazepine sensitivity. A mechanism of action of ACTH is proposed.