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The Outcome of Pregnancies before and after the Birth of Infants with Nervous System Malformations
Author(s) -
SMITHELLS R. W.,
D'ARCY E. E.,
McALLISTER E. F.
Publication year - 1968
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.1968.tb04824.x
Subject(s) - anencephaly , neural tube , spina bifida , medicine , incidence (geometry) , breed , pediatrics , obstetrics , birth weight , pregnancy , biology , embryo , physics , genetics , optics , microbiology and biotechnology
SUMMARY Amongst 1,683 viable infants born prior to the birth of 719 propositi with neural tube defects, the incidence of similar defects was 4–2 per cent. Amongst 313 viable infants born subsequent to the birth of 220 propositi with anencephaly and spina bifida, 5.1 per cent had neural tube defects. There is a tendency for particular neural tube defects to ‘breed true’ within sibships, and this is most marked when more than two sibs are affected.