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The Rate of Exchange of 24 Na and Other Ions between Plasma and Cerebrospinal Fluid in Normal Subjects and in Hydrocephalic Infants
Author(s) -
Migliore A.,
Paoletti P.,
Villani R.
Publication year - 1965
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/j.1469-8749.1965.tb10938.x
Subject(s) - cerebrospinal fluid , hydrocephalus , communicating hydrocephalus , lumbar , reabsorption , medicine , lumbar puncture , ventricular system , sodium , intracranial pressure , chemistry , anesthesia , anatomy , surgery , kidney , organic chemistry
SUMMARY The authors have studied the rate of passage of tritiated water and various ions from plasma into ventricular and lumbar cerebrospinal fluid and vice versa in normal subjects and hydrocephalic infants. (1) In every case a positive gradient is formed for sodium in the cerebrospinal fluid. In hydrocephalic infants there is a delay in the formation of this gradient, which is related to the increase in the volume of the ventricular cavities and in the cerebrospinal fluid pressure. (2) In infants with congenital hydrocephalus there is no reabsorption after the intraventricular injection of 24 Na. In adults with postinflammatory hydrocephalus the rate of disappearance reaches about 40 per cent of the injected dose by 2 hours after injection.