Premium
Broad‐spectrum resistance of A rabidopsis C 24 to downy mildew is mediated by different combinations of isolate‐specific loci
Author(s) -
Lapin Dmitry,
Meyer Rhonda C.,
Takahashi Hideki,
Bechtold Ulrike,
Ackerveken Guido
Publication year - 2012
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/j.1469-8137.2012.04344.x
Subject(s) - biology , downy mildew , quantitative trait locus , genetics , locus (genetics) , introgression , inbred strain , gene , plant disease resistance , botany
Summary Most natural A rabidopsis thaliana accessions are susceptible to one or more isolates of the downy mildew pathogen H yaloperonospora arabidopsidis ( H pa ). However, A rabidopsis C 24 has proved resistant to all H pa isolates tested so far. Here we describe the complex genetic basis of broad‐spectrum resistance in C 24. The genetics of C 24 resistance to three H pa isolates was analyzed by segregation analysis and quantitative trait locus ( QTL ) mapping on recombinant inbred and introgression lines. Resistance of C 24 to downy mildew was found to be a multigenic trait with complex inheritance. Many identified resistance loci were isolate‐specific and located on different chromosomes. Among the C 24 resistance QTLs , we found dominant, codominant and recessive loci. Interestingly, none of the identified loci significantly contributed to resistance against all three tested H pa isolates. Our study demonstrates that broad‐spectrum resistance of A rabidopsis C 24 to H pa is based on different combinations of multiple isolate‐specific loci. The identified quantitative resistance loci are particularly promising as they provide an important basis for the cloning of susceptibility‐ and immunity‐related genes.