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Type‐2 histone deacetylases as new regulators of elicitor‐induced cell death in plants
Author(s) -
Bourque Stéphane,
Dutartre Agnès,
Hammoudi Valentin,
Blanc Sabrina,
Dahan Jennifer,
Jeandroz Sylvain,
Pichereaux Carole,
Rossignol Michel,
Wendehenne David
Publication year - 2011
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/j.1469-8137.2011.03788.x
Subject(s) - elicitor , histone , microbiology and biotechnology , programmed cell death , biology , acetylation , botany , biochemistry , apoptosis , gene
Summary• Plant resistance to pathogen attack is often associated with a localized programmed cell death called hypersensitive response (HR). How this cell death is controlled remains largely unknown. • Upon treatment with cryptogein, an elicitor of tobacco defence and cell death, we identified NtHD2a and NtHD2b, two redundant isoforms of type‐2 nuclear histone deacetylases (HDACs). These HDACs are phosphorylated after a few minutes’ treatment, and their rate of mRNAs are rapidly and strongly reduced, leading to a 40‐fold decrease after10 h of treatment. • By using HDAC inhibitors, RNAi‐ and overexpression‐based approaches, we showed that HDACs, and especially NtHD2a/b, act as inhibitors of cryptogein‐induced cell death. Moreover, in NtHD2a/b ‐silenced plants, infiltration with cryptogein led to HR‐like symptoms in distal leaves. • Taken together, these results show for the first time that type‐2 HDACs, which are specific to plants, act as negative regulators of elicitor‐induced cell death in tobacco ( Nicotiana tabacum ), suggesting that the HR is controlled by post‐translational modifications including (de)acetylation of nuclear proteins.

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