Premium
The gene balance hypothesis: implications for gene regulation, quantitative traits and evolution
Author(s) -
Birchler James A.,
Veitia Reiner A.
Publication year - 2010
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/j.1469-8137.2009.03087.x
Subject(s) - gene duplication , biology , gene , genetics , function (biology) , phenotype , regulation of gene expression , copy number variation , functional divergence , balance (ability) , evolutionary biology , gene family , gene expression , genome , neuroscience
Summary The gene balance hypothesis states that the stoichiometry of members of multisubunit complexes affects the function of the whole because of the kinetics and mode of assembly. Gene regulatory mechanisms also would be governed by these principles. Here, we review the impact of this concept with regard to the effects on the genetics of quantitative traits, the fate of duplication of genes following polyploidization events or segmental duplication, the basis of aneuploid syndromes, the constraints on cis and trans variation in gene regulation and the potential involvement in hybrid incompatibilities.