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DNA repair mechanisms in plants: crucial sensors and effectors for the maintenance of genome integrity
Author(s) -
Bray Clifford M.,
West Christopher E.
Publication year - 2005
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/j.1469-8137.2005.01548.x
Subject(s) - dna repair , photolyase , biology , dna damage , phototroph , effector , obligate , microbiology and biotechnology , genetics , computational biology , dna , photosynthesis , botany
Summary As obligate phototrophs, plants harness energy from sunlight to split water, producing oxygen and reducing power. This lifestyle exposes plants to particularly high levels of genotoxic stress that threatens genomic integrity, leading to mutation, developmental arrest and cell death. Plants, which with algae are the only photosynthetic eukaryotes, have evolved very effective pathways for DNA damage signalling and repair, and this review summarises our current understanding of these processes in the responses of plants to genotoxic stress. We also identify how the use of new and emerging technologies can complement established physiological and ecological studies to progress the application of this knowledge in biotechnology.ContentsSummary 1 I. Introduction 1 II. Photoreactivation 4 III. Excision repair pathways: BER, NER, mismatch repair 7 IV. DNA double‐strand break repair 10 V. Molecular responses to genotoxic stress 13 VI. Conclusions and future prospects 14Acknowledgements 15References 15